CD8A and autoimmune disease: The three patients with autoimmune disease (of which two were HAEhigh and one was HAElow) had higher proportions of effector memory T helper cells and lower proportions of naïve CD8+ T cells both compared to patients without autoimmune disease (p = 0.01 and p = 0.02, respectively) and compared to all healthy controls (p = 0.02 and p = 0.008, respectively).