TXN and mesothelioma: Modulation of thioredoxins and thioredoxin interacting protein (TXNIP) showed that TRX1 overexpression or knockdown of TXNIP attenuated NLRP3 inflammasome activation, reinforcing the role of inflammasome activation by oxidants and subsequent generation of proteins, IL-1B and HMGB1, linked to mesothelioma development (66, 67).