Disruptions in OPA1 function have been implicated in various diseases, including cardiomyopathy (Chen et al. 2012), Behr Syndrome (Bonneau et al. 2014), autosomal dominant optic atrophy (DOA) (Alexander et al. 2000; Delettre et al. 2000), metabolic stroke (Zerem et al. 2019), syndromic parkinsonism, and dementia (Carelli et al. 2015). The gene discussed is OPA1; the disease is autosomal dominant optic atrophy.