In 2017, Hernández‐Llodrà et al. found that in ISUP 1 PCa, single ERG positive immunostaining was associated with progression, and the combination with PTEN and prostein loss (the so‐called “triple hit”) was strongly linked to both adverse pathological features and PSA progression‐free survival [17]. This evidence concerns the gene SLC45A3 and posterior cortical atrophy.