Tau pathology is the major neuropathological feature of “primary” tauopathies such as microtubule‐associated protein tau (MAPT)‐related frontotemporal dementia (MAPT‐FTD), progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and Pick's disease. The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.