More than 70 LRRK2 autophosphorylation sites have subsequently been mapped (for a comprehensive review on LRRK2 autophosphorylation sites, please refer to Marchand et al. [25]) and several antibodies generated, with assessment of the Ser1292 autophosphorylation site, in particular, confirming that PD pathogenic missense mutations increase the kinase activity of LRRK2 [26]. This evidence concerns the gene LRRK2 and Parkinson disease.