Thus, the aim of this study was to simultaneously investigate the protein and gene expression levels of IL‐33, Fetuin A, and CK‐18 in PF and plasma of patients with coronary artery disease undergoing coronary artery bypass grafting (CABG), as well as their relationship with each other, thereby providing new insights into potential cardiac‐specific biomarkers for diagnosis and therapeutic intervention. The gene discussed is KRT18; the disease is coronary artery disorder.