The above evidence indicated that turmeric and its active components exerted anti-tumor activity mainly through modulation of tumor proliferation, tumor invasion and metastasis, tumor angiogenesis, etc. The mechanisms were involved in targeting PI3K/Akt, JAK/STAT3, Hedgehog/Gli1, PPARγ, JNK/ERK signaling pathways. The gene discussed is GLI1; the disease is neoplasm.