FGF1 and pancreatic adenocarcinoma: Our findings of the highest level of HSPGs with the use of FGF1HSBCD biosensor present in pancreatic carcer cell line support previous reports on increased level of HSPGs in pancreatic adenocarcinoma cells and highlight the feasibility of the developed FGF1 variant as HS/HSPG sensor [36, 40–43].