TLR9 is the dominant TLR in B cells, and it is highly expressed in the dark and light zones subcomponent of the germinal center and TLR9 can, by binding to CpG DNA, drive B-cell proliferation and survival through NF-kB activation, a hallmark of activated B-cell (ABC) DLBCL. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.