These loops were located in the following six JIA risk regions: JAK1 (chr1:64,661,309–64851277), AFF3-LONRF2 (chr2:100,208,154–100273161, and chr2:100,208,154–100273161), WDFY4 (chr10:48,581,280–48686719), ZFP36L1 (chr14:68,790,795–68851245), TYK2 (chr19:10,363,179–10430870), and IL2RB (chr22:37,139,351–37,210,641). The gene discussed is LONRF2; the disease is juvenile idiopathic arthritis.