KLK3 and Familial prostate cancer: On the basis of the presence of BAT in PPAT, we hypothesize that multiparametric magnetic resonance imaging (mpMRI) incorporating chemical shift imaging detecting BAT on the basis of a higher water-to-fat ratio, when combined with serum prostate-specific antigen (PSA), could serve as a promising noninvasive predictive tool in prostate cancer risk stratification.