ANXA1 and colorectal carcinoma: The observation that F. nucleatum preferentially binds to CRC cells expressing the β-catenin modulator ANXA1 which has been reported to be overexpressed in 5-FU-resistant colon cancer cells, has suggested a link between F. nucleatum infection and chemoresistance (Onozawa et al, 2017; Rubinstein et al, 2019).