ELANE and pancreatic neoplasm: Moreover, another way by which P. gingivalis alters tumor immunity is by favoring the recruitment of immunosuppressive TANs via the upregulation of neutrophil-attracting chemokines (e.g., Cxcl1, Cxcl2, and Cxcr2) and elevating neutrophil elastase (NE) secretion in pancreatic cancer (Tan et al, 2022).