SQSTM1 and hepatocellular carcinoma: Impaired degradation of p62 via autophagy has been reported in HCC from NASH in several mouse models (Inokuchi-Shimizu et al, 2014; Nakagawa et al, 2014; Umemura et al, 2016; Zhang et al, 2015), suggesting that defective autophagy is a primary cause.