Structures known as Mallory-Denk bodies, which are positive for p62, KEAP1, and ubiquitin, have been observed in various liver disorders, including NASH and HCC (Ichimura et al, 2013; Inami et al, 2011; Stumptner et al, 2002). This evidence concerns the gene SQSTM1 and metabolic dysfunction-associated steatohepatitis.