Previous studies have reported impaired autophagic degradation of p62 bodies in multiple mouse models of non-alcoholic steatohepatitis (NASH)-derived hepatocellular carcinoma (HCC) (Inokuchi-Shimizu et al, 2014; Nakagawa et al, 2014; Umemura et al, 2016; Zhang et al, 2015). Here, SQSTM1 is linked to metabolic dysfunction-associated steatohepatitis.