SQSTM1 and Hyperkeratosis: This is explained by the fact that, in knock-in mice expressing p62S351E, in which autophagy is intact but p62 strongly binds to KEAP1, hyperkeratosis is observed in the stratified squamous epithelium of the esophagus and stomach, but the mice showed only mild liver enlargement and damage (Ikeda et al, 2023).