To test this, we used a Drosophila melanogaster model of TDP-43-mediated neurotoxicity, in which the ectopic expression of the human TDP-43 (hTDP-43) in the fly ommatidia causes progressive retinal degeneration, as shown by a significant reduction of the eye area, which is not associated to a diminished proliferation of ommatidial cells in the larvae [71] (Figs. 7C, D, S6). The gene discussed is TARDBP; the disease is retinal degeneration.