The contributions of this paper include: (1) evaluation of CRP omics measures in a Hispanic population; (2) addressing the knowledge gap regarding the associations between MRS-CRP and sleep traits; (3) exploring associations between CRP omics measures with sleep, metabolic syndrome and cognitive function in a Hispanic population; (4) identification of specific CpG sites as potential links of the sleep-CRP association. The gene discussed is CRP; the disease is metabolic syndrome.