Out of the list of the 1,041 CpG sites used in the construction of the MRS-CRP score, lasso penalized regression identified 66 and 12 CpG sites as associated with OSA and minimum SpO2 (log transformed), respectively, yet 0 CpG sites for average SpO2, insomnia and long sleep duration (Table S8-S9). The gene discussed is CRP; the disease is insomnia measurement.