CRP and insomnia measurement: As shown in Fig. 3B, MRS-CRP is also associated with higher risks of insomnia (odds ratio (OR) = 1.19 [1.02, 1.38]) and long sleep duration (OR = 1.29 [1.08, 1.55]), while blood CRP level is associated with lower risks of EDS (OR = 0.81 [0.68, 0.96]), longer overall sleep duration (0.13 [0.04, 0.21]), and increased risk of long sleep duration (OR = 1.31, [1.13, 1.53]).