Importantly, AlphaFold predictions support the presence of a similarly organized Fercore in all remaining paralogs, including otoferlin, whose mutations cause the nonsyndromic deafness DFNB9 and are a target of the first inner ear gene-therapy trials (Lv et al, 2024; Moser et al, 2024) (Appendix Fig. S15A,D). The gene discussed is OTOF; the disease is nonsyndromic deafness.