DYSF and autosomal recessive limb-girdle muscular dystrophy type 2B: The central physiological role of dysferlin in maintaining the integrity of muscle cell membranes is evident from over 400 disease-causing DYSF mutations identified in limb-girdle muscle dystrophy type 2B (LGMD2B) and Miyoshi myopathy (MM)—rare autosomal recessive muscle wasting disorders characterized by deficiencies in sarcolemma repair (Bansal et al, 2003; Cooper and Head, 2015).