BRAF and rectal cancer: In ten subgroups assembled according to primary tumour location and MMR-status, with pMMR tumours further subdivided by RAS/BRAF mutation status, the shortest OS after metastasectomies was seen in patients in the RAS&BRAFwt/pMMR right colon subgroup (44 months) and the longest in patients with RAS&BRAFwt/pMMR rectal cancers (93 months; Fig. 1B).