Among nine subgroups defined according to primary tumour location, and RAS- and BRAF-status, mOS after metastasectomy was the shortest among patients with BRAF-V600Emt right colon cancers (29 months) and the longest among patients with RAS&BRAFwt rectal cancers (95 months; Fig. 1, Supplementary Fig. S7A–I). This evidence concerns the gene BRAF and rectal cancer.