As the HRs for total mortality were the highest in the high NT-proANP tertile and in subjects with CVDs, CKD, DM or related medications at baseline, and the lowest in subjects without CVDs, CKD, DM or related medications at baseline, and NT-proANP levels had predictive value for CVD mortality, the results suggest that NT-proANP levels are inconsequential for deaths not related to CVDs. Here, NPPA is linked to chronic kidney disease.