Moreover, we found a significant negative correlation between RNF20 levels and the levels of HIF1α, the glucose transporter GLUT1 and glycolytic enzymes in lung adenocarcinoma and SCLC patients, suggesting the inhibition of glucose uptake or HIF1α as a promising approach for the treatment of lung cancer patients with decreased RNF20 levels. The gene discussed is RNF20; the disease is lung adenocarcinoma.