Moreover, in line with the survival data, showing that decreased RNF20 mRNA levels are associated with decreased survival only in AD patients but not in SC patients, we observed decreased survival in AD patients expressing high level of SLC2A1, ENO1, LDHA and VEGFA, but not in squamous cell carcinoma patients (Supplementary Fig. 7c, d). The gene discussed is ENO1; the disease is Alzheimer disease.