Consistent findings were observed with siRNA-mediated silencing of RNF20 in the human small-cell lung cancer cell line H82 (Fig. 6k–m), as well as with the ablation of a single Rnf20 allele in murine Lewis lung carcinoma (LLC1) cells (Supplementary Fig. 5a–k). This evidence concerns the gene RNF20 and small cell lung carcinoma.