Importantly, in line with our cell culture-based assays, HIF1A silencing or inhibition of glucose uptake with the GLUT1 inhibitor WZB117 was sufficient to suppress the metabolic changes (Fig. 7g) and reduce both the number of tumor nodules and the metastatic area in mice injected with RNF20 + /- A549 cells (Fig. 7h–j). Here, RNF20 is linked to neoplasm.