ALPI and cancer: Treatment with sodium butyrate (NaBT), a histone deacetylase inhibitor which induces normal intestinal and cancer cell differentiation [20], induced enterocyte differentiation as demonstrated by dramatic increases in IAP activity and expression of enterocyte marker KRT20 expression in HT29 cells, these increases were significantly attenuated by overexpression of HK1 in HT29 cells (Supplementary Fig. 6).