Compared with that in the control group, the half-life of HIF2α was considerably extended in 786O and OSRC2 cells overexpressing CYP1B1, whereas SU-R RCC cells with CYP1B1 knockdown exhibited a markedly reduced HIF2α protein half-life (Fig. 5D and S5B). The gene discussed is CYP1B1; the disease is renal cell carcinoma.