For the 851 samples with a single known subtype, the softmax scores of the ALLIUM predictions were unequally distributed by true subtype, with, for example, T-ALL and ZNF384-r showing consistently high scores for the correct subtypes only and with other subtypes such as BCR::ABL1 and BCR::ABL1-like receiving high scores in more than 1 class (Fig 1B). This evidence concerns the gene ZNF384 and acute lymphoblastic leukemia.