Notably, while Piezo1 KO HF-SCs still enter the quiescent telogen, the duration of telogen progressively decreased from ~21 days after the initial deletion of Piezo1 (cycle #3) to ~10 days by the 10th hair cycle (Fig. 4F), suggesting an accumulative effect of Piezo1 ablation on HF-SC quiescence. The gene discussed is PIEZO1; the disease is hydrops fetalis.