The widespread impact on cell adhesion and actin cytoskeleton genes caused by Piezo1 deletion is reminiscent of the perturbed transcriptome detected in Nfatc1 cKO HF-SCs (Fig. 6, A and B) (35), a key TF known for its role in regulating HF-SC quiescence and aging (35, 44, 45). The gene discussed is NFATC1; the disease is hydrops fetalis.