FTO-mediated removal of m6A from ETS domain-containing protein Elk-3 (ELK3) mRNA enhances its stability, leading to increased levels of ELK3, which in turn activates the transcription of glycolysis-related genes, such as phosphoglycerate kinase 1 (PGK1), thereby promoting glycolysis in T-ALL. This evidence concerns the gene PGK1 and acute lymphoblastic leukemia.