FTO and acute lymphoblastic leukemia: To establish NOTCH1-induced T-ALL murine model (25), we transduced MigR1–ICN1 (intracellular NOTCH1) retroviruses, with green fluorescent protein (GFP) as a surrogate marker, into bone marrow (BM) lineage negative (Lin−) cells from Ftofl/fl, Fto−/−, Alkbh5fl/fl, or Alkbh5−/− mice and transplanted these cells into irradiated recipient mice (Fig. 1B).