MT-CO1 and hyperinsulinemic hypoglycemia, familial, 4: On the basis of this, we investigated whether PNU142586 inhibits mitochondrial transcription and protein translation by monitoring the expression of MT-CO1, a protein crucial in mitochondrial complex IV deficiency encoded by the mitochondrial genome (24–26), in HL-60 and THP-1 cells treated with LZD and PNU142586.