The most common signaling pathways were prolactin signaling pathway, PPAR signaling pathway, diabetic cardiomyopathy, Insulin resistance, VEGF signaling pathway, FoxO signaling pathway, lipid and atherosclerosis, nuclear receptors, Urotensin II-mediated signaling pathway, AGE-RAGE pathway, IL 26 signaling pathways, PPAR signaling pathway, Oxidative stress response and IL-6 signaling pathway. The gene discussed is VEGFA; the disease is Insulin resistance.