FKBP5 and depressive disorder: We speculated that polymorphisms in the FKBP5 gene would be associated with TMJ in adolescents due to the emotional and psychological aspects that influence the etiology of TMD4,5 and the fact that polymorphisms in this gene have previously been associated with post-traumatic stress disorder,25 anxiety,23 depressive disorder,23,24 and surgical discomfort.24 However, TMJ was not associated with polymorphisms in the FKBP5 gene in the present study.