Serum cartilage oligomeric matrix proteins (COMP), bone alkaline phosphatase (bALP), osteocalcin, PINP, synovial fluid hyaluronic acid and MMP‐1 levels at 0 h, 15, 30 and 60 days in dogs with osteoarthritis treated with meloxicam and pentoxifylline (Mean ± SD). The gene discussed is COMP; the disease is osteoarthritis.