Particularly, transcriptional program for a mesenchymal MMP-dependent motility (i.e., EMT) is triggered in myocardial cells through Snail1 lactylation following myocardial infarction [35] as well as in thyroid and renal carcinomas through LDHA- or Sirtuin 1-dependent mechanisms [36–38]. Here, SIRT1 is linked to thyroid gland disorder.