YAP1 and cancer: Upstream of the pathway is a complex signaling network, and downstream relies on YAP/TAZ binding to transcription factors (TEAD, p73, RUNX, and TBX5), which promotes cell proliferation, survival, and stemness, and thus the regeneration of cardiac, hepatic, and intestinal tissues in mice.[76a] Similar to the ECM/Integrin/FAK pathway, the Hippo pathway has been associated with the progression of cancer and fibrosis, even with the unintended side effect of muscle degeneration.[76] In response, Moya et al.