PIEZO1 and osteoarthritis: In cartilage, studies link PIEZO1/2 activation to chondrocyte apoptosis and matrix degradation in osteoarthritis, suggesting a pathological role.[56] In skin wound healing, inhibiting PIEZO1 accelerates keratinocyte migration and reduces scarring, fostering a regenerative phenotype.[57] In neural regeneration, PIEZO1 acts as an endogenous inhibitor of axon regrowth, whereas PIEZO2 contributes to neuropathic pain post‐injury.[58] These findings highlight the pleiotropic nature of PIEZO channels, necessitating a nuanced understanding of their tissue‐specific roles.