C4B and infection: Notably, knockdown of ch-hnRNPM resulted in a significant reduction in the titers of WSN, H9N2, PR8, and H5N1W (the HA and NA of the H5N1W recombinant virus are derived from WSN) viruses at 24 to 48 h post-infection (Fig. 6D through G), suggesting that ch-hnRNPM also plays a critical role in IAV replication.