We found that hu-hnRNPM knockdown reduced the transcription of IRF3 and interferon-stimulated genes (ISGs), including Mx1, ISG15, and IFITM3, both in the absence and presence of WSN or VSV virus infection in A549 cells (Fig. 3A through D). This evidence concerns the gene IFITM3 and early-onset parkinsonism-intellectual disability syndrome.