We found that hu-hnRNPM knockdown reduced the transcription of IRF3 and interferon-stimulated genes (ISGs), including Mx1, ISG15, and IFITM3, both in the absence and presence of WSN or VSV virus infection in A549 cells (Fig. 3A through D). The gene discussed is ISG15; the disease is early-onset parkinsonism-intellectual disability syndrome.