To investigate the mechanism by which SAMHD1 enhances apoptosis induced by HIV-1 infection through the mitochondrial pathway, the expression of BCL-2 family proteins in THP-1 Ctrl and SAMHD1 KO cell lines infected with HIV-1NL4-3 and with or without NVP at 2–8 dpi was measured by Western blot. This evidence concerns the gene SAMHD1 and HIV-1 infection.