By contrast, the protein levels of BCL-2, BCl-XL, BAX, BAK, BIM, and BID (Fig. S7B), as well as mRNA levels of BAX (Fig. S7D), were not affected by SAMHD1 expression or HIV-1NL4-3 infection of THP-1 cell lines. The gene discussed is SAMHD1; the disease is infection.