The expression of BIK in THP-1 Ctrl cells, with or without HIV-1 infection, was higher than that in SAMHD1 KO cells at 2, 4, 6, and 8 dpi (Fig. 6A and B; Fig. S7A), while the expressions of BCL-2, BCL-XL, BAX, BAK, BIM, and BID were not affected by SAMHD1 expression, HIV-1 infection, or NVP treatment (Fig. S7A), suggesting that SAMHD1-enhanced apoptosis is associated with increased BIK expression. Here, SAMHD1 is linked to HIV-1 infection.