The percentages of total apoptosis in THP-1 Ctrl and SAMHD1 KI cells, which expressed similar levels of SAMHD1 protein, were higher than that observed in SAMHD1 KO and Lvx cells upon HIV-1-Luc/VSV-G infection (Fig. 2B and C; Fig. S1B). The gene discussed is SAMHD1; the disease is infection.