Loss of BIK expression reverted Δψm in SAMHD1-expressing THP-1 cells, but not in SAMHD1 KO cells, upon HIV-1 infection, suggesting that BIK is required for SAMHD1-enhanced mitochondrial depolarization by HIV-1 (Fig. 7E; Fig. S9B). The gene discussed is SAMHD1; the disease is HIV-1 infection.