IFITM1 and infection: The weak anti-HBV effects in cells transiently expressing IFITM1 C505184S indicated that the antiviral activity of IFITM1 on HBV depended on palmitoylation modification (Fig. 2); together with the confirmation that ABHD16A interacts with IFITM1 (Fig. 3) and regulates the infection of HBV (Fig. 4 and 5), we speculated that ABHD16A may regulate the process of IFITM1’s resistance to HBV infection through depalmitoylation.