The CKLF Like MARVEL Transmembrane Domain Containing (CMTM) gene family has been identified as a key regulator of tumorigenesis, although its precise role in OC progression remains poorly understood.[11] Notably, CMTM4, a member of this gene family, has been implicated in immune modulation and tumor progression.[12] While the involvement of exosomal CMTM4 in immune regulation has been proposed, its specific mechanisms in OC remain unclear. This evidence concerns the gene CMTM4 and neoplasm.