Data from TCGA further revealed that TGFβ1 and CXCL12 exhibited the highest expression levels and were predominantly expressed in M2 macrophages compared to other immune cell types, suggesting that their expression in macrophages may be regulated by tumor‐derived exosomal CMTM4 (Figure S13C‐D, Supporting Information). Here, CMTM4 is linked to neoplasm.