In research from other fields, ICAM1 has been shown to facilitate the secretion of TGFβ1 and CXCL12 via interaction with macrophages, therefore we determined whether CMTM4 in tumor‐derived exosomes enhances macrophage secretion of these cytokines through ICAM1 upregulation or NF‐κB activation.[21, 22] As anticipated, both si‐ICAM1 and PDTC treatment effectively reduced the elevated secretion of these factors (Figure 5C; Figure S13F, Supporting Information). The gene discussed is CXCL12; the disease is neoplasm.