The metabolomics analysis conducted above showed that Fn‐positive CRC patients and Fn‐infected mice showed enhanced lipid biosynthesis and energy metabolism, and the blood triglyceride (TG) test confirmed that TG in the MF group was higher than that in the M and control groups, but it declined in the SynCom groups though not significantly (Figure 5F). The gene discussed is FN1; the disease is colorectal carcinoma.