And the diversity of platelet membrane receptors in activated PRP was confirmed to selectively capture and bind LPS and multiple chemo‐ and cytokines including TNF‐α, IFN‐γ and IL‐1β, and drive the macrophages polarization toward M2 phenotype, which could synergistically block the chronic inflammatory feedback loop and regulate immune homeostasis of periodontitis. The gene discussed is IFNG; the disease is periodontitis.