More importantly, CCS‐RSF@PRP hydrogel elicited high selectivity for capturing and binding LPS and multiple chemo‐ and cyto‐kines, including TNF‐α, IFN‐γ, and IL‐1β, and driving the macrophages polarization toward M2 phenotype, which could synergistically block the chronic inflammatory feedback loop, mitigate the destructive inflammatory microenvironment in periodontal, and restore immune homeostasis of periodontitis, owing to the diversity of platelet membrane receptors and signal factors in activated PRP. The gene discussed is TNF; the disease is periodontitis.