As shown in Figure 5f–h, compared with the control group, the levels of LPS, TNF‐α, and IL‐1β in the periodontium at day 28 were significantly downregulated after treated with CCS‐RSF@PRP hydrogels, indicating the hydrogel effectively neutralized these proinflammatory mediators, thereby regulating the repeated and chronic inflammation and improving the tissue regeneration of periodontitis. This evidence concerns the gene TNF and periodontitis.