IL1B and periodontitis: As shown in Figure 5f–h, compared with the control group, the levels of LPS, TNF‐α, and IL‐1β in the periodontium at day 28 were significantly downregulated after treated with CCS‐RSF@PRP hydrogels, indicating the hydrogel effectively neutralized these proinflammatory mediators, thereby regulating the repeated and chronic inflammation and improving the tissue regeneration of periodontitis.