SIRT2 and respiratory system disorder: [38, 39] In contrast, the two K40 deacetylases, HDAC6 and sirtuin 2 (SIRT2), promote ciliary disassembly.[40, 41] Furthermore, various studies have demonstrated that HDAC6‐mediated ciliary disassembly plays a crucial role in maintaining tissue homeostasis and in various ciliopathies such as respiratory disorders, retinal diseases, male infertility, and cancer.