For example, the ubiquitination of the centrosomal kinase tau tubulin kinase 2 (TTBK2) by HUWE1 (HECT, UBA, and WWE domain‐containing protein 1) promotes its degradation, leading to the disassembly of primary cilia and suggesting a potential target for medulloblastoma therapy.[22] Furthermore, CP110 levels are regulated by ubiquitination via the SCF‐cyclin F and EDD‐DDB1‐VprBP complexes, along with the deubiquitinase USP33, influencing the conversion of the mother centriole to the basal body and offering a strategy to inhibit tumorigenesis linked to centrosome amplification.[23, 24, 25]. The gene discussed is HUWE1; the disease is medulloblastoma.