CXCR2 and neoplasm: Consistent with these findings, studies have demonstrated that the CXCL‐CXCR2 signaling axis promotes tumor growth, the homing of mature neutrophils into tissues, and invasiveness.[29] These results suggest that APM‐naïve tumor cells enhance neutrophil infiltration to promote bone metastasis by upregulating the expression of Cxcr2 and activating the Cxcl‐Cxcr2 signaling axis.