Among these, papillary thyroid carcinoma (PTC) is the most common, accounting for over 90% of thyroid cancer cases.[1] The use of high‐resolution ultrasound has increased the detection rate of papillary thyroid microcarcinoma (PTMC), defined as PTC with a maximum diameter of ≤1 cm, which significantly contributes to the rising global incidence of PTC.[2] Several signaling pathways, such as MAPK/ERK and PI3K/AKT, are implicated in thyroid cancer pathogenesis; however, the mechanisms driving PTC progression, particularly in PTMC, remain poorly understood. This evidence concerns the gene AKT1 and thyroid cancer.