PROS1 and cancer: TAM receptors, which function as carcinogenic receptors on tumor cells and immunosuppressive receptors on immune cells, play pivotal roles in tumor progression and immune evasion, marking a new frontier in cancer biology.[35, 36, 37, 38] By screening signaling pathways in the CellChat database based on the progression levels in PTC (normal < stage I < stage II ≤ stage III), the ligands PROS1 and the MERTK receptor in the TAM pathway were identified as closely associated with PTC progression.