For instance, NFYB can be activated by E2F1 in osteosarcoma and E2F4 in hepatocellular carcinoma.[48, 49] FOXP2 is primarily regulated by various noncoding RNAs, including let‐7b, miR‐34a, miR‐762, SNHG1, and miR‐23b, in breast cancer, glioma, and colon cancer.[50, 51, 52] Furthermore, recent work by Yu et al. This evidence concerns the gene E2F1 and osteosarcoma.