CD4 and colorectal cancer: These findings indicated that the NM@PLGA‐MTI‐OXA nanodrug reverses the Fn‐mediated immunosuppressive microenvironment, increases cytotoxic CD8+ and CD4+ T cell infiltration, effectively reduces inflammatory cytokine expression in the colorectal cancer mouse model, and enhances the efficacy of the chemotherapeutic agent oxaliplatin after clearing intratumoral bacteria.