The results showed that compared to the control group, the expression of VCAM1(Figure S6A, Supporting Information), CD44(Figure S6B, Supporting Information), and ICAM1(Figure S6C, Supporting Information) was upregulated in Fn‐infected CT26 cells, and more NM@PLGA‐Cy5.5 particles were observed which suggested that the high expression of adhesion molecules facilitates the adhesion of NM@PLGA‐Cy5.5 to tumor cells, ensuring efficient uptake of NM@PLGA‐Cy5.5 by the tumor cells. The gene discussed is ICAM1; the disease is neoplasm.