Colorectal cancer serves as a prime example of pathogen‐tumor symbiosis, with Fn being one of the most well‐established intratumoral pathogens in colorectal cancer, promoting its development.[26] In response to this challenge, multiple studies have focused on developing synergistic anti‐tumor strategies targeting Fusobacterium nucleatum based on nanomaterials to enhance the efficacy of chemotherapy and immunotherapy. The gene discussed is FN1; the disease is colorectal cancer.