EMT, a key molecular step in colorectal cancer distant metastasis, is typically accompanied by the expression of mesenchymal markers such as vimentin, Slug, Snail, and N‐cadherin.[25] Mechanistically, the impact of NM@PLGA‐MTI‐OXA on the expression of EMT‐related proteins in tumor cells infiltrated by Fn was evaluated. The gene discussed is FN1; the disease is colorectal cancer.