In recent years, advances in detection techniques and a deeper understanding of the tumor microenvironment have yielded increasing evidence confirming the presence of intratumoral bacteria.[8, 9, 10, 11]Fusobacterium nucleatum (Fn), a common member of the human oralmicrobiome, canspecifically bind to Gal‐GalNac, which is highly expressed on colorectal cancer cells, via its surface protein FAP2. Here, FN1 is linked to neoplasm.