Previous studies have revealed that IL‐1 can mobilize and recruit the MDSC and neutrophil to shape an immunosuppressive microenvironment, which might repress the T cell‐mediated antitumor function.[18, 21, 22] Correspondingly, correlation analysis showed that IL‐1 expression was positively correlated with several immunosuppressive cells’ infiltration, hypoxia, and T cells exhaustion while negatively correlated with the infiltration level of CD8+ T cells in gastric cancer (Figure 4F,G). This evidence concerns the gene CD8A and gastric cancer.