Immunohistochemistry and flow cytometry experiments (Figure 5H–J; Figure S4I, Supporting Information) demonstrated that targeting IL‐1/IL‐1R1 signaling can increase the infiltration abundance of CD8+ T cells and M1‐type macrophages in the TME and activate cytotoxic T lymphocytes (CTLs) to secrete cytotoxic factors, shifting the TME toward a hot tumor phenotype. This evidence concerns the gene IL1R1 and neoplasm.