QSOX1, a well‐characterized sulfhydryl oxidase, has been shown to protect against oxidative stress‐induced cell death in vitro.[30] Our recent study has revealed that high QSOX1 expression in dormant tumors maintains a high oxidation niche, which promotes dormant CSCs immune escape by upregulating the expression of PD‐L1 and itself, and promoting CD8+ T‐cell exclusion.[5] Therefore, QSOX1 may promote tumor cell survival mainly by regulating the oxidative microenvironment. The gene discussed is CD8A; the disease is neoplasm.