AKT1 and esophageal squamous cell carcinoma: Intriguingly, treatment with Akt inhibitor MK‐2206 led to an increase in the molecular weight of TSC2 in the protein lysates from ESCC cells supplemented with PEG‐mal, suggesting that both QSOX2 and Akt are involved in the disulfide bond formation of TSC2 (Figure 5H).