As to why eGFR correlates with oncological outcomes, it has been suggested that cardiovascular disease complications and VEGFR‐TKI‐specific adverse events due to hypertension, diarrhea, and anorexia may lead to further decline in renal function, resulting in inadequate response to VEGFR‐TKI treatment [28, 29, 30]. The gene discussed is KDR; the disease is cardiovascular disorder.