The diminished capacity for polyamine and arginine metabolism, which are linked to enhanced IgA responses and vascular function (Durante, 2013, Durante, 2022; Rodriguez et al., 2017; Falck-Jones et al., 2021; Martí I Líndez and Reith, 2021; Zhao et al., 2023), further underscores the potential for metabolic impairment to contribute to severe COVID-19 outcomes. This evidence concerns the gene CD79A and COVID-19.