Furthermore, poly-GR–induced mislocalization of Nup62 leads to the formation of insoluble Nup62:TDP-43 inclusions, which are widely detected in postmortem central nervous system CNS tissues of patients with C9orf72-associated ALS and sALS (Gleixner et al., 2022). Here, C9orf72 is linked to amyotrophic lateral sclerosis.