Recent studies have revealed that in aged AD brains, post-mitotic hippocampal cells begin to express lamin A in the early course of the disease, leading to a more intricate nuclear lamin structure that includes lamin B1, B2, and A, compared to healthy aged neurons (Figure 4) (Gil et al., 2020; Mendez-Lopez et al., 2019). This evidence concerns the gene LMNB1 and Alzheimer disease.