This study preliminarily explores the correlation between GSTP1 gene rs1695, rs4891 sites; HMOX1 gene rs2071747, rs17878790 sites; CAT gene rs7943316, rs1049982, rs769217 sites; EPHX1 gene rs2234922, rs41266231, rs1051740 sites SNPs and the risk of childhood asthma in Fuzhou, aiming to further elucidate the pathogenesis of asthma and provide new insights and targets for the diagnosis and treatment of bronchial asthma. The gene discussed is HMOX1; the disease is childhood onset asthma.