Dyslipidemia plays a major role on the increased risk of cardiovascular events, CVD-related, and all-cause mortality due to an increase in atherogenic lipoproteins such as Apo B that may become entrapped within the subendothelial space and undergo oxidation and scavenging by arterial macrophages, resulting in endothelial dysfunction and formation of foam cells, fatty streaks, and atherosclerotic plaque. The gene discussed is APOB; the disease is endothelial dysfunction.