The immunohistochemical analysis of NOD1 and NOD2 expression in cattle with different types of lesions associated with paratuberculosis provides a snapshot of the immunological events ongoing in the intestine of these animals at the moment of euthanasia, allowing the characterization of the immune cell populations expressing these receptors and their distribution in relation to MAP-associated granulomas. This evidence concerns the gene NOD2 and Granuloma.