In this study, we characterized the TCR and BCR repertoires by detecting and analyzing CDR3 sequences in the TCR α, β, γ, and δ chains, as well as B-cell immunoglobulin (Ig) heavy (IGH) and light (IGK/IGL) chains, in B-ALL patients with different clinical characteristics. Here, BCR is linked to precursor B-cell acute lymphoblastic leukemia.